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Spatial pattern gene: GNG4 (spascer ID:2786) |
Gene summary for GNG4 |
| Gene summary |
| Gene information | |
| Species | Human |
| Gene symbol | GNG4 |
| Gene ID | 2786 |
| Gene name | G protein subunit gamma 4 |
| Synonyms | HG3C |
| Cytomap | 1q42.3 |
| Type of gene | protein-coding |
| Description | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4guanine nucleotide binding protein (G protein), gamma 4guanine nucleotide binding protein 4heterotrimeric guanine nucleotide-binding protein 3C |
| Modification date | 20220513 |
| UniProtAcc | P50150 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| GNG4 | GO:0005834 | heterotrimeric G-protein complex | 21873635 | Component |
| GNG4 | GO:0007186 | G protein-coupled receptor signaling pathway | 21873635 | Process |
| GNG4 | GO:0031681 | G-protein beta-subunit binding | 21873635 | Function |
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Spatial pattern events for GNG4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| GNG4 | Human | Bladder | rep_2 | 34385456 | 2.17e-14 |
| GNG4 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| GNG4 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| GNG4 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
| Bladder_rep_2_H&E | |
| Intestine_rep_colon1_H&E | |
| Liver_rep_liver1_H&E | |
| Liver_rep_liver2_H&E | |
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Spatial pattern pathway has GNG4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Brain | rep_1 | 2.8e-23 |
| GNG4 | GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Brain | rep_1 | 2.8e-23 |
| GNG4 | GOBP_Cell_Growth | Human | Brain | rep_4 | 1.0e-14 |
| GNG4 | GOBP_Growth | Human | Brain | rep_4 | 1.0e-14 |
| GNG4 | GOBP_Cell_Growth | Human | Liver | rep_1 | 2.1e-52 |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Liver | rep_1 | 1.0e-70 |
| GNG4 | GOBP_Growth | Human | Liver | rep_1 | 2.1e-52 |
| GNG4 | GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Liver | rep_1 | 1.0e-70 |
| GNG4 | GOBP_Cell_Growth | Human | Intestine | rep_colon2 | 1.5e-57 |
| GNG4 | GOBP_Growth | Human | Intestine | rep_colon2 | 1.5e-57 |
| GNG4 | GOBP_Cell_Growth | Human | Intestine | A3 | 1.3e-16 |
| GNG4 | GOBP_Growth | Human | Intestine | A3 | 3.3e-16 |
| GNG4 | GOBP_Negative_Regulation_Of_Cell_Growth | Human | Intestine | A3 | 2.6e-16 |
| GNG4 | GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Intestine | A3 | 1.1e-07 |
| GNG4 | GOBP_Regulation_Of_Growth | Human | Intestine | A3 | 3.6e-10 |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Intestine | A8 | 1.4e-14 |
| GNG4 | GOBP_Negative_Regulation_Of_Growth | Human | Intestine | A8 | 3.4e-21 |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Uterus | rep_26 | 3.5e-06 |
| GNG4 | GOBP_Negative_Regulation_Of_Cell_Growth | Human | Uterus | rep_26 | 3.0e-09 |
| GNG4 | GOBP_Negative_Regulation_Of_Growth | Human | Uterus | rep_26 | 2.4e-09 |
| GNG4 | GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Uterus | rep_26 | 4.8e-06 |
| GNG4 | GOBP_Cell_Growth | Human | Breast | rep_1 | 6.0e-15 |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Breast | rep_1 | 3.6e-09 |
| GNG4 | GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Breast | rep_1 | 0.0e+00 |
| GNG4 | GOBP_Regulation_Of_Growth | Human | Breast | rep_1 | 2.3e-04 |
| GNG4 | GOBP_Growth | Human | Breast | rep_5 | 5.4e-12 |
| GNG4 | GOBP_Cell_Growth | Human | Skin | P9_rep3 | 4.1e-08 |
| GNG4 | GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway | Human | Lung | rep_2 | 4.8e-08 |
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GNG4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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GNG4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for GNG4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for GNG4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GNG4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |